Clearance dynamics of lactate dehydrogenase and aldolase following antimalarial treatment for Plasmodium falciparum infection
نویسندگان
چکیده
منابع مشابه
Antimalarial Activity of Potential Inhibitors of Plasmodium falciparum Lactate Dehydrogenase Enzyme Selected by Docking Studies
The Plasmodium falciparum lactate dehydrogenase enzyme (PfLDH) has been considered as a potential molecular target for antimalarials due to this parasite's dependence on glycolysis for energy production. Because the LDH enzymes found in P. vivax, P. malariae and P. ovale (pLDH) all exhibit ∼90% identity to PfLDH, it would be desirable to have new anti-pLDH drugs, particularly ones that are effe...
متن کاملStudy of total serum lactate dehydrogenase activity as an indirect evidence of acute Plasmodium falciparum infection
Background : Lactate dehydrogenase (LDH) activity was assayed in the sera of 40 adult male and 40 adult female patients within the age group of 16-50 years presenting with acute, Plasmodium falciparum malaria infection and a control group of 40 healthy adults within the same age group. Study objective: Study was design to determine diagnostic value of serum LDH activity in patient with acute P....
متن کاملTotal serum lactate dehydrogenase activity in acute Plasmodium falciparum malaria infection.
INTRODUCTION Lactate dehydrogenase (LDH) activity was assayed in the sera of 76 adult male and 76 adult female patients within the age group of 18-40 years presenting with acute, uncomplicated Plasmodium falciparum malaria infection and a control group of 80 healthy adults within the same age group. METHODS Patient selection and pre-qualification were done by simple random sampling of individ...
متن کاملDNA Sequence Polymorphism of the Lactate Dehydrogenase Genefrom Iranian Plasmodium vivax and Plasmodium falciparum Isolates
BACKGROUND Parasite lactate dehydrogenase (pLDH) is extensively employed as malaria rapid diagnostic tests (RDTs). Moreover, it is a well-known drug target candidate. However, the genetic diversity of this gene might influence performance of RDT kits and its drug target candidacy. This study aimed to determine polymorphism of pLDH gene from Iranian isolates of P. vivax and P. falciparum. METH...
متن کاملPersistent histidine-rich protein 2, parasite lactate dehydrogenase, and panmalarial antigen reactivity after clearance of Plasmodium falciparum monoinfection.
We tested 240 patients with Plasmodium falciparum monoinfection for persistent parasite antigenemia after successful standardized antimalarial therapy by using the ICT Malaria Pf/Pv and OptiMAL-IT assays that detect the malaria antigens Plasmodium falciparum histidine-rich protein 2 (HRP2) and parasite lactate dehydrogenase (pLDH), respectively, as well as a panmalarial antigen (PMA). The patie...
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ژورنال
عنوان ژورنال: Parasites & Vectors
سال: 2019
ISSN: 1756-3305
DOI: 10.1186/s13071-019-3549-x